Our Previous Findings Using Microarray Have Revealed Downregulation Of MiR-150 And Overexpression Of Its Possible Target, RAD54L In Local Multiple Myeloma Patients And Cell Lines. It Has Been Shown That MiRNA Could Bind To The Target Gene To Regulate Its Expression Through MRNA Degradation Or Protein Repression. RAD54L And MiR-150 Has Been Shown To Play A Critical Role In Various Cancers; However, Its Role In The Molecular Pathogenesis Of Multiple Myeloma Is Unknown. In This Study, We Aimed To Study The Function Of RAD54L And The Biological Relevance Of MiR-150-RAD54L Using In Vitro Model. KMS-28BM Multiple Myeloma Cell Line Was Used As Host Cell In This Study. RAD54L Was Silenced Using SiRNA And The Function Of RAD54L In Cell Proliferation, Apoptosis And Cell Cycle Were Measured With MTS And Flow Cytometry, Respectively. Gene Expression And Protein Expression Were Measured Using RT-qPCR And ELISA Methods. Statistical Analysis Was Performed Using Student T-test To Compared The Control And Treated Groups, Where P<0.05 Was Considered As Statistically Significance.
National Health And Morbidity Survey (NHMS) 2018: Elderly Health Was Part Of NHMS V (2015-2018). The Objective Of This Survey Was To Provide Health Related Community-based Data And Information To The Ministry Of Health To Review Health Priorities, Program Strategies And Activities, And To Plan For The Allocation Of Resources For Pre-elderly And Elderly Health Care Services. This Survey Was Conducted As A Nation-wide Community-based Survey Targeting Elderly Aged 60 Years Or More And Pre-elderly Aged 50 To 59 Years. Data Was Collected Via Face To-face Interview At Respondent’s Homes Using Mobile Devices With Various Assessments Done Based On Topics. A Total Of 5,636 Living Quarters Were Approached With 7,117 Respondents Successfully Interviewed.
The UNDERPHEN Study Was Consigned By The Disease Control Division At Ministry Of Health As Part Of The National Strategic Plan For Cancer Control And Prevention (NSP-CCP) Documents To Answer The World Health Organization’s (WHO) Social And Development Goals (SDG). This Project Was Fully Funded By The Ministry Of Health Malaysia, Project Code NMRR-19-862-46635. This Study Obtained Ethical Clearance From The Ministry Of Health Malaysia – KKM/ NIHSEC/P19-1453(7) And Was Carried Out In 1 Year Duration. Designed As A Qualitative Study, The Outcomes Of The Study Intended To Understand The Experiences And Feedback From The Patient’s Point Of View As Increasing Numbers Of Cancer Is Detected, The Challenges Of Services Provision Is Needed To Be Addressed. This Study Is Meant To Provide An Overview Of The Process Involved In Study In Revealing The Findings Of Data Collection Conducted. Findings Included Delays In The Various Stages Of Cancer Through The Health Services In The Perspectives Of The Participants. Delays Found Are Type Specific And Varies In Stages Of Delay Are Subject To Cancer Type. The Main Delays Are In The Treatment Phase And The Major Aspects Are Diagnosis And Treatment Errors, Miscommunication Between Patient And Provider, Limitations In Access To Health Providers And Services, The Patient’s Internal Issues That In The End Led To An Issue Of Distrust. These Findings Are Integral To Understand The Struggles And How Services Can Be Improved. This Study Is Meant For Policy Makers, Stakeholders, Funding Agencies And Those Who Are Interested In The Study Topic. The Findings Will Detail The Reasons Of Why Delay Occurs In Cancer Treatment And This Will Provide An Insight On How To Tackle The Delays On The Implementers Side Via Modification Of Existing Guidelines And Practices.