This Study Is A Cross-sectional Survey Based On Discrete Choice Experiment (DCE) Method. The Main Idea Is To Develop Several Choice Sets In The Survey, Using Factors/attributes Related To Covid-19 Vaccination Uptake Obtained From Extensive Literature Search And Opinions From Experts And Policy Makers. For Each Choice Task, There Will Be Two Options Of Hypothetical Covid-19 Vaccination Programme Alternatives And One Opt-out Options. The Options Are Described In Terms Of Attributes With Different Levels. Respondents Are Asked To Choose Which Programme They Prefer. By Making Choices From Repetitive Hypothetical Scenarios, We Will Be Able To Understand What Trade-offs Between Attributes Levels That The Respondents Are Willing To Make. Objectives: To Understand The Determinants Of Malaysia Public’s Vaccination Preferences And Decision Making Through Discrete Choice Experiment Specific Objectives: • To Systemically Determine The Important Attributes For Uptake Of Covid-19 Vaccination Among Malaysian Public • To Determine Preferences For Covid-19 Vaccination Among Different Groups With Sociodemographic Factors Such As Gender, Race, Age, Marital Status, Household Income Etc. Inclusion Criteria • All Malaysian Citizens Age 18 Years Old And Above • Able To Understand And Read Malay/English/Mandarin Reported Public Uptake Of COVID-19 Vaccination Was Primarily Influenced By The Risk Of Developing Severe Side Effects (b = −1·747, 95% CI = −2·269, -1·225), Vaccine Effectiveness (b = 3·061, 95% CI = 2·628, 3·494) And Its Halal Status (b = 3·722, 95% CI = 3·152, 4·292). Other Factors Such As Appointment Timing And Travel Distance To The Vaccination Centre Also Had An Effect On Vaccine Uptake. There Was Substantial Heterogeneity In Preferences Between Different Populations, Particularly For Age Groups, Ethnicity, Regions, And Underlying Health Conditions. Interpretation: Perceived Effectiveness And Side Effects Are Likely To Affect COVID-19 Vaccine Uptake In Malaysia. Halal Content Is Critical To Malays’ Vaccination Choices. Reducing The Physical Distance To Vaccination Centres, Particularly In Rural Areas Where Uptake Is Lower, Is Likely To Improve Uptake. DOI: 10.1016/j.lanwpc.2022.100534