The caregivers of cancer patients suffer from psychological distress which ultimately affects their Quality of Life (QOL) with increasing burden of treatment over the cancer patients. A US Institute Medicine report stated that measurement of QOL is needed for public accountability, internal quality improvement and research on effectiveness of interventions to improve outcomes in patient with life threatening illness and their families (Cheung 2019-6). Majority of the published studies on the association between caregivers’ QOL and socio-demography have been conducted on Caucasian populations (Chamber et al., 2013). The finding of those studies may not be directly applicable to the Malaysian population due to different socio-cultural and ethnic background. To the best our knowledge, to date, no other validated disease-specific instrument in Malay available to evaluate QOL of caregiver with advanced cancer patients and factors that associate with it. OBJECTIVES 1) To validate Malay-CQOLC on content validity among caregivers of advanced cancer patients 2) To validate Malay-CQOLC on construct validity among caregivers of advanced cancer patients 3) To validate Malay-CQOLC on feasibility and reliability among caregivers of advanced cancer patients MATERIALS & METHODS: This is a cross-sectional study performed from September 2022 to April 2024. A total of 310 cancer caregivers from cancer centre in Johor participated in the study. The Malay-CQOLC scale has 35 items consist of 4 domains namely burden, positive adaptation, disruptiveness and financial concern. All socio-demographic data and QOL profile were evaluated descriptively. Internal consistency and construct validity was determined by cronbach’s alpha and principle axis factoring extraction test respectively.