This research develops an open science model for research data management at the Malaysia National Institutes of Health (NIH), a leading health research organization in the country. It addresses the challenge of low researcher participation observed during the initial implementation of the NIH-Data Repository System (NIH-DaRS). Recognizing the importance of open science in promoting collaboration, transparency, and accessibility of research, this research aimed at investigating the readiness of the researchers and institutes to embrace open science practices.