Developed by the Global Burden of Disease (GBD) study, Burden of Disease is a summary measure of population health. The overall burden of disease, measured in DALY, combines the potential Years of Life Lost (YLL) due to premature death and the Years Lost due to Disability (YLD), an equivalent of potential healthy years lost due to poor health, illness or disability. The present study aims to provide a comprehensive assessment of premature mortality and morbidity (non-fatal health outcomes) attributable to diseases and injuries by age and sex specific for 2015 until 2017. Therefore, the objectives can be specified as follow: 1. To calculate the burden of premature mortality (YLLs) by age and gender in Malaysia for 2015 until 2017. 2. To calculated the burden of morbidity (YLDs) by age and gender in Malaysia for 2015 until 2017. 3. To calculate the Disability Adjusted Life Years (DALYs) by age and gender in Malaysia for 2015 until 2017. The study used secondary data available for estimating the burden of diseases. The data selected range from 2015 until 2017, involving both mortality and morbidity data. The data where then estimated into the burden analysis for each diseases and conditions. The outcome of this study was to estimate the leading cause of death and burden of disease and injury by gender and age-specific in Global Burden of Disease format. All the findings will be used by the researchers in NIH, IKN, DOSM and MOH HQ for research purposes, policy driven programs, and financial budgeting in healthcare.